We investigate and specialize at the interface of receptor trafficking and signaling as well as the integrity of the cytoskeleton- and how one affects the other. In this context, we are especially interested in spatio-temporal regulation and diversification. Therefore, our general approach to answer scientific questions is non-linear, investigating mechanisms in parallel and not as single, isolated units. We study these mechanisms during development and apply our findings translationally to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth (CMT) disease.